SPR可以进行药物靶量测量，从药物-膜的相互作用，到药物-细胞的相互作用。在实时和无标记的情况下区分内部和渗透。研究细胞在不同涂层的附着情况。
基于细胞的研究有很多，包括组织工程、体外毒物学、药物输送，还有抗菌涂料。表面等离子体共振最初是用于蛋白质相互作用测量的。直到近年来，研究人员才开始开发SPR来研究活细胞。
我们的一些用户使用SPR来测量细胞在不同的生物材料和涂层表面的扩散或粘附。
SPR也可作为生物传感器用于检测细胞特定代谢物以确定细胞分化和细胞功能
一些小组正在研究生物膜的形成或抗菌涂料
五个选择SPR检查活细胞的原因
1. 能够实时测量活细胞和细菌附着
2. 能够在未标记的情况下区分渗透和内吞
3. 表面非特异性吸附情况
4. 温度和剪切应力的控制
5. SPR与电化学的结合
SPR可以回答的关于活细胞的五个关键性问题
1. 药物吸收途径是什么?
2. 哪一种纳米颗粒是药物输送的最佳载体?
3. 一种纳米粒子或病毒是如何进入细胞的?
4. 细胞附着在表面上的动力学是什么?
5. 哪一种表面最能抵抗细菌的生长?
参考文献
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6. Structural and Viscoelastic Properties of Layer-by-Layer Extracellular Matrix (ECM) Nanofilms and Their Interactions with Living Cell, ACS Biomater. Sci. Engineering, 2015, 1[9]: p. 816–824
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